عامل فون ويليبراند (الإنكليزية: von Willebrand Factor <vWF>) وهو أحد عوامل التخثر.
في الصفيحات الدموية ، البروتين المستلم لهذا العامل يدعى بـ GPIbIXV.
نقص او إنعدام العامل يسبب مرض فون ويليبراند (von Willebrand Disease <VWD>).
| رقم أو اسم عامل التخثر | الوضيفة |
|---|---|
| I (فيبرينوجين) | Forms clot (fibrin) |
| II (بروثرومبين) | Its active form (IIa) activates I, V, VII, XIII, protein C, platelets |
| Tissue factor | Co-factor of VIIa (formerly known as factor III) |
| كالسيوم | Required for coagulation factors to bind to phospholipid (formerly known as factor IV) |
| V (proaccelerin, labile factor) | Co-factor of X with which it forms the prothrombinase complex |
| VI | Unassigned – old name of Factor Va |
| VII (stable factor) | Activates IX, X |
| VIII (antihemophilic factor) | Co-factor of IX with which it forms the tenase complex |
| IX (Christmas factor) | Activates X: forms tenase complex with factor VIII |
| X (Stuart-Prower factor) | Activates II: froms prothrombinase complex with factor V |
| XI (plasma thromboplastin antecedent) | Activates XII, IX and prekallikrein |
| XII (Hageman factor) | Activates prekallikrein and fibrinolysis |
| XIII (fibrin-stabilizing factor) | Crosslinks fibrin |
| عامل فون ويليبراند | Binds to VIII, mediates platelet adhesion |
| prekallikrein | Activates XII and prekallikrein; cleaves HMWK |
| high molecular weight kininogen (HMWK) | Supports reciprocal activation of XII, XI, and prekallikrein |
| فايبرونيكتين | Mediates cell adhesion |
| ضد الثرومبين III | Inhibits IIa, Xa, and other proteases; |
| heparin cofactor II | Inhibits IIa, cofactor for heparin and dermatan sulfate ("minor antithrombin") |
| بروتين C | Inactivates Va and VIIIa |
| بروتين S | Cofactor for activated protein C (APC, inactive when bound to C4b-binding protein) |
| بروتين Z | Mediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPI |
| Protein Z-related protease inhibitor (ZPI) | Degrades factors X (in presence of protein Z) and XI (independently) |
| plasminogen | Converts to plasmin, lyses fibrin and other proteins |
| alpha 2-antiplasmin | Inhibits plasmin |
| tissue plasminogen activator (tPA) | Activates plasminogen |
| urokinase | Activates plasminogen |
| plasminogen activator inhibitor-1 (PAI1) | Inactivates tPA & urokinase (endothelial PAI) |
| plasminogen activator inhibitor-2 (PAI2) | Inactivates tPA & urokinase (placental PAI) |
| cancer procoagulant | Pathological factor X activator linked to thrombosis in cancer |